|
KMID : 0624620150480080479
|
|
BMB Reports
2015 Volume.48 No. 8 p.479 ~ p.484
|
|
|
Antimicrobial peptide scolopendrasin VII, derived from the centipede Scolopendra subspinipes mutilans, stimulates macrophage chemotaxis via formyl peptide receptor 1
|
|
Park Yoo-Jung
Lee Ha-Young
Jung Young-Su
Park Joon-Seong
Hwang Jae-Sam
Bae Yoe-Sik
|
|
|
Abstract
|
|
|
|
In this study, we report that one of the antimicrobial peptides scolopendrasin VII, derived from Scolopendra subspinipes mutilans, stimulates actin polymerization and the subsequent chemotactic migration of macrophages through the activation of ERK and protein kinase B (Akt) activity. The scolopendrasin VII-induced chemotactic migration of macrophages is inhibited by the formyl peptide receptor 1 (FPR1) antagonist cyclosporine H. We also found that scolopendrasin VII stimulate the chemotactic migration of FPR1-transfected RBL-2H3 cells, but not that of vector-transfected cells; moreover, scolopendrasin VII directly binds to FPR1. Our findings therefore suggest that the antimicrobial peptide scolopendrasin VII, derived from Scolopendra subspinipes mutilans, stimulates macrophages, resulting in chemotactic migration via FPR1 signaling, and the peptide can be useful in the study of FPR1-related biological responses.
|
|
|
KEYWORD
|
|
|
Antimicrobial peptide, Chemotaxis, Formyl peptide receptor 1, Macrophage, Scolopendrasin VII
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|